# DDX5

Source: https://onco.cc/targets/ddx5/  
OnCo record `ddx5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.

## Summary

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEAD-box helicase 5; Probable ATP-dependent RNA helicase DDX5; p68; HLR1; G17P1
- Tags: cancer-genes-wave
- Symbol: DDX5
- Class: transcription
- Biology: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergises with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Location: Nucleus; Nucleus, nucleolus; Nucleus speckle; Cytoplasm (UniProt). Locus 17q23.3 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2746: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2746
- UniProt P17844: https://www.uniprot.org/uniprotkb/P17844/entry
- NCBI Gene 1655: https://www.ncbi.nlm.nih.gov/gene/1655
- Ensembl ENSG00000108654: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108654

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ddx5.json