# DDX6

Source: https://onco.cc/targets/ddx6/  
OnCo record `ddx6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DDX6 (Probable ATP-dependent RNA helicase DDX6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Lung cancer, Leiomyosarcoma and 1 more.

## Summary

Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.10, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Leiomyosarcoma, Medulloblastoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEAD-box helicase 6; Probable ATP-dependent RNA helicase DDX6; Rck/p54; HLR2
- Tags: cancer-genes-wave
- Symbol: DDX6
- Class: enzyme
- Biology: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Location: Cytoplasm, P-body; Cytoplasm; Nucleus; Cytoplasm, Cytoplasmic ribonucleoprotein granule (UniProt). Locus 11q23.3 (HGNC).
- Where found: Sarcomas: IntOGen driver in 1 cohort (LMS); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903); Leiomyosarcoma: IntOGen driver in 1 cohort (LMS); Medulloblastoma: IntOGen driver in 1 cohort (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2747: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2747
- UniProt P26196: https://www.uniprot.org/uniprotkb/P26196/entry
- NCBI Gene 1656: https://www.ncbi.nlm.nih.gov/gene/1656
- Ensembl ENSG00000110367: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110367

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leiomyosarcoma](https://onco.cc/cancers/leiomyosarcoma/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/), [Sarcomas (soft tissue, bone, GIST)](https://onco.cc/cancers/sarcoma/)

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JSON: https://onco.cc/api/v1/entities/ddx6.json