# DecisionDx-UM

Source: https://onco.cc/drugs/decisiondx-um/  
OnCo record `decisiondx-um` (Test). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A test on a small sample of an eye melanoma that measures 15 transcripts to estimate how likely it is to spread, often to the liver.

## Summary

Medicare's Palmetto MolDX policy L37033 describes DecisionDx-UM as "an ribonucleic acid (RNA) gene expression classifier" of "15 mRNA transcripts (3 control and 12 discriminating genes)" and provides "limited coverage" for managing newly diagnosed uveal melanoma in patients with a confirmed diagnosis and no evidence of metastatic disease. In the prospective Collaborative Ocular Oncology Group validation of 459 patients, metastasis was detected in 3 class 1 cases (1.1 per cent) and 44 class 2 cases (25.9 per cent) (Onken 2012).

## Fields

- Kind: Test
- Status: established
- Last checked: 2026-11-04
- Also known as: uveal melanoma gene expression profile; 15-gene uveal melanoma classifier
- Tags: test; rna
- Brand: DecisionDx-UM
- Modality: Gene-expression prognostic assay (15 transcripts, uveal melanoma)
- Mechanism: An RNA classifier of 12 discriminating and 3 control transcripts, run on fine-needle aspirate or fixed tumour tissue, assigns class 1 (lower) or class 2 (higher) risk of metastasis.

## Sources

- Castle Biosciences: DecisionDx-UM: https://www.castlebiosciences.com/tests/prognostic/decisiondx-um/
- CMS LCD L37033: MolDX: DecisionDx-UM (Uveal Melanoma): https://www.cms.gov/medicare-coverage-database/view/lcd.aspx?lcdid=37033

## Connected records

- cancers: [Uveal melanoma](https://onco.cc/cancers/uveal-melanoma/)
- technologies: [Gene-expression prognostic assays](https://onco.cc/technologies/gene-expression-prognostic-assays/)
- companies: [Castle Biosciences](https://onco.cc/companies/castle-biosciences/)
- key papers: [Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma](https://onco.cc/key-papers/paper-onken-uveal-melanoma-gene-expression-coog-ophthalmology-2012/)

---
JSON: https://onco.cc/api/v1/entities/decisiondx-um.json