# DEK

Source: https://onco.cc/targets/dek/  
OnCo record `dek` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.

## Summary

Involved in chromatin organisation.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DEK proto-oncogene; D6S231E
- Tags: cancer-genes-wave
- Symbol: DEK
- Class: other
- Biology: Involved in chromatin organisation. Location: Nucleus (UniProt). Locus 6p22.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2768: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2768
- UniProt P35659: https://www.uniprot.org/uniprotkb/P35659/entry
- NCBI Gene 7913: https://www.ncbi.nlm.nih.gov/gene/7913
- Ensembl ENSG00000124795: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124795

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/dek.json