# Denise R. Aberle

Source: https://onco.cc/people/denise-aberle/  
OnCo record `denise-aberle` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Principal investigator of the National Lung Screening Trial, which first proved CT screening saves lives.

## Summary

Denise Aberle was national principal investigator of the ACRIN arm of the National Lung Screening Trial, whose 2011 result of a 20% reduction in lung cancer mortality with low-dose CT led to the first lung screening recommendations and Medicare coverage in the United States. She continues to work on quantitative imaging and AI for nodule assessment.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: screening; lung; radiology
- Role: Professor of Radiology and Bioengineering, UCLA
- Specialisms: Thoracic radiology; Lung cancer screening; Imaging trials; Quantitative imaging

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Denise_Aberle
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Aberle%20DR%5BAuthor%5D%20lung%20screening

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [AI in radiology](https://onco.cc/technologies/radiology-ai-screening/), [CT (computed tomography)](https://onco.cc/technologies/ct/)
- institutions: [UCLA Jonsson Comprehensive Cancer Center](https://onco.cc/institutions/ucla-jonsson/)
- trials: [NLST & NELSON (low-dose CT screening)](https://onco.cc/trials/nlst-nelson/)
- key papers: [NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers](https://onco.cc/key-papers/paper-nlst-nejm-2011/)

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