# DKK1

Source: https://onco.cc/targets/dkk1/  
OnCo record `dkk1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DKK1 (Dickkopf-related protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Antagonises canonical Wnt signalling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalisation of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Irinotecan, Levoleucovorin, Oxaliplatin and Fluorouracil.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: dickkopf Wnt signaling pathway inhibitor 1; Dickkopf-related protein 1; DKK-1
- Tags: cancer-genes-wave
- Symbol: DKK1
- Class: other
- Biology: Antagonises canonical Wnt signalling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalisation of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Location: Secreted (UniProt). Locus 10q21.1 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2891: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2891
- UniProt O94907: https://www.uniprot.org/uniprotkb/O94907/entry
- NCBI Gene 22943: https://www.ncbi.nlm.nih.gov/gene/22943
- Ensembl ENSG00000107984: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107984

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/dkk1.json