# DLL4

Source: https://onco.cc/targets/dll4/  
OnCo record `dll4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DLL4 (Delta-like protein 4) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Involved in the Notch signalling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes clinical 0.18, affected pathway 0.91, literature 0.98, genetic association 0.00, animal model 0.26). In OnCo, 1 product record names it (Tovecimig).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: delta like canonical Notch ligand 4; Delta-like protein 4
- Tags: cancer-genes-wave
- Symbol: DLL4
- Class: surface-antigen
- Biology: Involved in the Notch signalling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. Location: Cell membrane (UniProt). Locus 15q15.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.18; a membrane or secreted protein (UniProt keywords) that 1 antibody-based OnCo product name. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2910: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2910
- UniProt Q9NR61: https://www.uniprot.org/uniprotkb/Q9NR61/entry
- NCBI Gene 54567: https://www.ncbi.nlm.nih.gov/gene/54567
- Ensembl ENSG00000128917: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128917

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- drugs: [Tovecimig](https://onco.cc/drugs/tovecimig/)

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JSON: https://onco.cc/api/v1/entities/dll4.json