# DLST

Source: https://onco.cc/targets/dlst/  
OnCo record `dlst` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DLST (Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.

## Summary

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: dihydrolipoamide S-succinyltransferase; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; OGDC-E2; KGD2
- Tags: cancer-genes-wave
- Symbol: DLST
- Class: enzyme
- Biology: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localises in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Location: Mitochondrion matrix; Nucleus (UniProt). Locus 14q24.3 (HGNC).
- Where found: Neuroendocrine tumours: Open Targets association 0.66 with neuroendocrine neoplasm (MONDO_0019496)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2911: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2911
- UniProt P36957: https://www.uniprot.org/uniprotkb/P36957/entry
- NCBI Gene 1743: https://www.ncbi.nlm.nih.gov/gene/1743
- Ensembl ENSG00000119689: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119689

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/)

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JSON: https://onco.cc/api/v1/entities/dlst.json