# DNAJB1

Source: https://onco.cc/targets/dnajb1/  
OnCo record `dnajb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DNAJB1 (DnaJ homolog subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.00, somatic mutation 0.90).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: DnaJ heat shock protein family (Hsp40) member B1; DnaJ homolog subfamily B member 1; Hsp40; Sis1; RSPH16B; HSPF1
- Tags: cancer-genes-wave
- Symbol: DNAJB1
- Class: other
- Biology: Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 19p13.12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5270: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5270
- UniProt P25685: https://www.uniprot.org/uniprotkb/P25685/entry
- NCBI Gene 3337: https://www.ncbi.nlm.nih.gov/gene/3337
- Ensembl ENSG00000132002: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132002

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/dnajb1.json