# DNAJC12

Source: https://onco.cc/targets/dnajc12/  
OnCo record `dnajc12` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DNAJC12 is a co-chaperone gene that is strongly expressed in oestrogen receptor-positive (luminal) breast cancers and is used as a luminal marker.

## Summary

UniProt describes DNAJC12 as an Hsp40 co-chaperone that helps fold the aromatic amino acid hydroxylases. In breast cancer it is an oestrogen-responsive gene that separates luminal from basal-like tumours in expression data, and one of the genes whose protein closely follows its transcript.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: DnaJ heat shock protein family (Hsp40) member C12; JDP1
- Tags: cansim-terms
- Symbol: DNAJC12
- Class: other
- Biology: Probable co-chaperone for the folding of biopterin-dependent aromatic amino acid hydroxylases (PAH, TH, TPH1 and TPH2); expressed at high levels in brain, heart and testis (UniProt Q9UKB3).
- Where found: Locus 10q21.3 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:28908: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28908
- UniProt Q9UKB3: https://www.uniprot.org/uniprotkb/Q9UKB3/entry

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/), [Hormone receptor status (ER / PR)](https://onco.cc/terms/hormone-receptor-status/), [mRNA to protein concordance](https://onco.cc/terms/mrna-protein-concordance/), [PAM50 / intrinsic subtypes](https://onco.cc/terms/pam50/)

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JSON: https://onco.cc/api/v1/entities/dnajc12.json