# DNX-2440

Source: https://onco.cc/drugs/dnx-2440/  
OnCo record `dnx-2440` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DNX-2440 is an experimental oncolytic adenovirus from DNAtrix, in phase 1 trials for colorectal cancer liver metastases, liver metastases from other solid tumours and recurrent glioblastoma; development is paused.

## Summary

DNX-2440 is an oncolytic adenovirus from DNAtrix. An oncolytic adenovirus expressing OX40 ligand, a costimulatory molecule expected to enhance T-cell responses against the tumour. Its furthest stage is phase 1, for colorectal cancer liver metastases, liver metastases from other solid tumours and recurrent glioblastoma. ClinicalTrials.gov registers it in 2 studies linked below. NCT04714983 (DNAtrix, liver metastases) is SUSPENDED: 'DNAtrix management decision not based on study design, safety, or site performance.' NCT03714334 (Navarra, recurrent glioblastoma) TERMINATED: 'Break of stock'. Registry checked 3 Nov 2026. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: DNX-2440
- Modality: Oncolytic adenovirus
- Mechanism: An oncolytic adenovirus expressing OX40 ligand, a costimulatory molecule expected to enhance T-cell responses against the tumour.

## Sources

- DNAtrix: biospace.com: https://www.biospace.com/dnatrix-announces-first-patient-dosed-in-clinical-study-of-dnx-2440-an-ox40-ligand-expressing-immunotherapy-in-colorectal-cancer-and-other-cancers-with-liver-metastasis
- DNAtrix: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT04714983
- ClinicalTrials.gov: trials of DNX-2440: https://clinicaltrials.gov/search?intr=DNX-2440

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- companies: [DNAtrix](https://onco.cc/companies/dnatrix/)
- trials: [DNX-2440 for Resectable Colorectal Liver Metastasis](https://onco.cc/trials/nct04714983/), [DNX-2440 Oncolytic Adenovirus for Recurrent Glioblastoma](https://onco.cc/trials/nct03714334/)

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JSON: https://onco.cc/api/v1/entities/dnx-2440.json