# DOCK8

Source: https://onco.cc/targets/dock8/  
OnCo record `dock8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DOCK8 (Dedicator of cytokinesis protein 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.79, genetic association 0.52, genetic literature 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: dedicator of cytokinesis 8; Dedicator of cytokinesis protein 8; FLJ00026; FLJ00152; ZIR8; FLJ00346
- Tags: cancer-genes-wave
- Symbol: DOCK8
- Class: other
- Biology: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarisation of microtubule-organising centre (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. Location: Cytoplasm; Cell membrane; Cell projection, lamellipodium membrane (UniProt). Locus 9p24.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19191: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19191
- UniProt Q8NF50: https://www.uniprot.org/uniprotkb/Q8NF50/entry
- NCBI Gene 81704: https://www.ncbi.nlm.nih.gov/gene/81704
- Ensembl ENSG00000107099: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107099

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/dock8.json