# Dositinib

Source: https://onco.cc/drugs/dositinib/  
OnCo record `dositinib` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Dositinib is an experimental small molecule from Henan Genuine Biotech, in phase 2 trials for EGFR-mutant non-small cell lung cancer.

## Summary

Dositinib (90-1408, 哆希替尼) is a small molecule (oral EGFR tyrosine kinase inhibitor) from Henan Genuine Biotech. An EGFR tyrosine kinase inhibitor taken as a tablet. Its furthest stage is phase 2, for EGFR-mutant non-small cell lung cancer. ClinicalTrials.gov registers it in 2 studies linked below. Phase 1/2 NCT07231068 in EGFR-mutant NSCLC recruiting (started October 2022); also in NCT07362940 with GEN-725. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-2
- Last checked: 2026-11-03
- Also known as: 90-1408; 哆希替尼
- Tags: pipeline; ctgov-ingest
- Code: Dositinib
- Modality: Small molecule (oral EGFR tyrosine kinase inhibitor)
- Mechanism: An EGFR tyrosine kinase inhibitor taken as a tablet.

## Sources

- Henan Genuine Biotech: clinicaltrials.gov: https://clinicaltrials.gov/study/NCT07231068
- Henan Genuine Biotech: genuine-bio.com: https://genuine-bio.com/research.html
- ClinicalTrials.gov: trials of Dositinib: https://clinicaltrials.gov/search?intr=Dositinib

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- targets: [EGFR](https://onco.cc/targets/egfr/)
- companies: [Henan Genuine Biotech](https://onco.cc/companies/henan-genuine-biotech/)
- trials: [A Dose-escalation and Dose-expansion Phase I/Phase II Clinical Study of Dositinib Mesylate Tablets (90-1408) in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer With Positive EGFR Mutation](https://onco.cc/trials/nct07231068/), [A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib](https://onco.cc/trials/nct07362940/)

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