# Doxycycline

Source: https://onco.cc/drugs/doxycycline/  
OnCo record `doxycycline` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Doxycycline is an antibiotic tablet. People starting EGFR-blocking cancer drugs often take it for the first weeks to make the acne-like rash milder.

## Summary

The US label covers a long list of bacterial infections. The MASCC EGFR inhibitor guideline (2011) states: "Hydrocortisone 1% combined with moisturizer, sunscreen, and doxycycline 100 mg bid for the first 6 weeks is recommended based on randomized data", and notes that doxycycline appears safer with renal dysfunction while minocycline is less photosensitising. The amivantamab (Rybrevant) label tells prescribers to give an oral antibiotic, "doxycycline or minocycline, 100 mg orally twice daily", from day 1 for the first 12 weeks. The Vibramycin NDA was approved on 5 December 1967.

## Fields

- Kind: Treatment
- Status: approved
- Last checked: 2026-11-11
- Tags: supportive; generic; supportive-care-gaps-2026-11
- Brand: Vibramycin / Doryx
- Modality: Tetracycline-class antibacterial (oral)
- Mechanism: A tetracycline-class antibacterial; in acneiform rash it is used for its anti-inflammatory effect as well as against bacteria.
- Approvals: US 1967: Bacterial infections including rickettsial, respiratory, urinary and sexually transmitted infections, and others listed on the label

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Doxycycline
- US label (DailyMed): doxycycline: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=00b2aa98-dea2-90c3-e063-6294a90a35d6
- Lacouture et al., MASCC clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities (Support Care Cancer 2011): https://doi.org/10.1007/s00520-011-1197-6
- US label (DailyMed): Rybrevant (amivantamab), rash prophylaxis: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1466c070-9f97-4fa4-a955-6a6b59981fb8

## Connected records

- drugs: [Amivantamab](https://onco.cc/drugs/amivantamab/), [Minocycline](https://onco.cc/drugs/minocycline/)
- terms: [Rash and skin toxicity (acneiform rash, paronychia)](https://onco.cc/terms/rash-skin-toxicity/)

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