# DUSP16

Source: https://onco.cc/targets/dusp16/  
OnCo record `dusp16` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.

## Summary

Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: dual specificity phosphatase 16; Dual specificity protein phosphatase 16; MKP-7; KIAA1700; MKP7
- Tags: cancer-genes-wave
- Symbol: DUSP16
- Class: tumor-suppressor
- Biology: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Location: Cytoplasm; Nucleus; Cytoplasmic vesicle (UniProt). Locus 12p13.2 (HGNC).
- Where found: Colorectal cancer: IntOGen driver in 2 cohorts (COADREAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17909: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17909
- UniProt Q9BY84: https://www.uniprot.org/uniprotkb/Q9BY84/entry
- NCBI Gene 80824: https://www.ncbi.nlm.nih.gov/gene/80824
- Ensembl ENSG00000111266: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111266

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/dusp16.json