# DUSP6

Source: https://onco.cc/targets/dusp6/  
OnCo record `dusp6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

DUSP6 (Dual specificity protein phosphatase 6) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: dual specificity phosphatase 6; Dual specificity protein phosphatase 6; MKP-3; PYST1
- Tags: cancer-genes-wave
- Symbol: DUSP6
- Class: enzyme
- Biology: Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. Location: Cytoplasm (UniProt). Locus 12q21.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3072: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3072
- UniProt Q16828: https://www.uniprot.org/uniprotkb/Q16828/entry
- NCBI Gene 1848: https://www.ncbi.nlm.nih.gov/gene/1848
- Ensembl ENSG00000139318: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139318

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/dusp6.json