# E2F7

Source: https://onco.cc/targets/e2f7/  
OnCo record `e2f7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

E2F7 is an unusual member of the E2F family that represses genes rather than activating them, helping cells pause after DNA damage.

## Summary

UniProt describes E2F7 as an atypical E2F that mainly represses transcription, recognising the E2 site without a DP partner and participating in the DNA damage response. It is a cell-cycle gene whose transcript and protein can diverge, one of the examples of decoupled mRNA and protein in proteogenomic data.

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: E2F transcription factor 7
- Tags: cansim-terms
- Symbol: E2F7
- Class: transcription
- Biology: Atypical E2F transcription repressor that binds DNA independently of DP proteins and acts in angiogenesis, polyploidisation and the DNA damage response (UniProt Q96AV8).
- Where found: Locus 12q21.2 (HGNC).

## Notes

- Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme.

## Sources

- HGNC HGNC:23820: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23820
- UniProt Q96AV8: https://www.uniprot.org/uniprotkb/Q96AV8/entry

## Connected records

- pathways: [p53 / RB / cell-cycle checkpoint](https://onco.cc/pathways/p53-cell-cycle/)
- terms: [Cancer AI vocabulary (CanSim terms map)](https://onco.cc/terms/cancer-ai-vocabulary/), [Co-amplification and the 17q12 HER2 amplicon](https://onco.cc/terms/co-amplification/), [mRNA to protein concordance](https://onco.cc/terms/mrna-protein-concordance/)

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JSON: https://onco.cc/api/v1/entities/e2f7.json