# EBF1

Source: https://onco.cc/targets/ebf1/  
OnCo record `ebf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EBF1 (Transcription factor COE1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Neuroendocrine tumours and 4 more.

## Summary

Key pioneer transcription factor of B-cell specification and commitment. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.93, animal model 0.43, genetic association 0.62, somatic mutation 0.83). IntOGen calls it a driver in 6 cohorts (3 activating, 3 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Lung Squamous Cell Carcinoma, Malignant Lymphoma, Non-Hodgkin Lymphoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: EBF transcription factor 1; Transcription factor COE1; OLF1; COE1
- Tags: cancer-genes-wave
- Symbol: EBF1
- Class: transcription
- Biology: Key pioneer transcription factor of B-cell specification and commitment. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold. In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency. Location: Nucleus (UniProt). Locus 5q33.3 (HGNC).
- Where found: Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254); Non-Hodgkin lymphoma: Open Targets association 0.62 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL); Neuroendocrine tumours: Open Targets association 0.55 with neuroendocrine neoplasm (MONDO_0019496); Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903); Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898); Diffuse large B-cell lymphoma: Open Targets association 0.54 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3126: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3126
- UniProt Q9UH73: https://www.uniprot.org/uniprotkb/Q9UH73/entry
- NCBI Gene 1879: https://www.ncbi.nlm.nih.gov/gene/1879
- Ensembl ENSG00000164330: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164330

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ebf1.json