# EBF2

Source: https://onco.cc/targets/ebf2/  
OnCo record `ebf2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.36, animal model 0.53, genetic association 0.64).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: EBF transcription factor 2; Transcription factor COE2; FLJ11500; COE2
- Tags: cancer-genes-wave
- Symbol: EBF2
- Class: transcription
- Biology: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19090: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19090
- UniProt Q9HAK2: https://www.uniprot.org/uniprotkb/Q9HAK2/entry
- NCBI Gene 64641: https://www.ncbi.nlm.nih.gov/gene/64641
- Ensembl ENSG00000221818: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221818

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ebf2.json