# ECSCR

Source: https://onco.cc/targets/ecscr/  
OnCo record `ecscr` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ECSCR (Endothelial cell-specific chemotaxis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Angiogenesis Inhibitor.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: endothelial cell surface expressed chemotaxis and apoptosis regulator; Endothelial cell-specific chemotaxis regulator; ECSM2
- Tags: cancer-genes-wave
- Symbol: ECSCR
- Class: other
- Biology: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Location: Cell membrane; Cytoplasm (UniProt). Locus 5q31.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:35454: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:35454
- UniProt Q19T08: https://www.uniprot.org/uniprotkb/Q19T08/entry
- NCBI Gene 641700: https://www.ncbi.nlm.nih.gov/gene/641700
- Ensembl ENSG00000249751: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000249751

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/ecscr.json