# EDNRA

Source: https://onco.cc/targets/ednra/  
OnCo record `ednra` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EDNRA (Endothelin-1 receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer.

## Summary

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, animal model 0.71, genetic association 0.00, clinical 0.85).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: endothelin receptor type A; Endothelin-1 receptor; ET-A; ETA-R; hET-AR
- Tags: cancer-genes-wave
- Symbol: EDNRA
- Class: other
- Biology: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Location: Cell membrane (UniProt). Locus 4q31.22-q31.23 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.85. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3179: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3179
- UniProt P25101: https://www.uniprot.org/uniprotkb/P25101/entry
- NCBI Gene 1909: https://www.ncbi.nlm.nih.gov/gene/1909
- Ensembl ENSG00000151617: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151617

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/ednra.json