# EED

Source: https://onco.cc/targets/eed/  
OnCo record `eed` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EED (Polycomb protein EED) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and the evidence so far is association rather than a proven role.

## Summary

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognises 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark.

Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.52, affected pathway 0.68, genetic association 0.19, somatic mutation 0.49). In OnCo, 1 product record names it (Rinzimetostat).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: embryonic ectoderm development; Polycomb protein EED; WAIT-1
- Tags: cancer-genes-wave
- Symbol: EED
- Class: transcription
- Biology: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognises 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. Location: Nucleus; Chromosome (UniProt). Locus 11q14.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3188: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3188
- UniProt O75530: https://www.uniprot.org/uniprotkb/O75530/entry
- NCBI Gene 8726: https://www.ncbi.nlm.nih.gov/gene/8726
- Ensembl ENSG00000074266: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000074266

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- drugs: [Rinzimetostat](https://onco.cc/drugs/rinzimetostat/)

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JSON: https://onco.cc/api/v1/entities/eed.json