# EFTUD2

Source: https://onco.cc/targets/eftud2/  
OnCo record `eftud2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EFTUD2 (116 kDa U5 small nuclear ribonucleoprotein component) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.

## Summary

Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: elongation factor Tu GTP binding domain containing 2; 116 kDa U5 small nuclear ribonucleoprotein component; U5-116KD; Snrp116; Snu114; SNRNP116
- Tags: cancer-genes-wave
- Symbol: EFTUD2
- Class: oncogene
- Biology: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Location: Nucleus (UniProt). Locus 17q21.31 (HGNC).
- Where found: Multiple myeloma: IntOGen driver in 1 cohort (PCM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:30858: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30858
- UniProt Q15029: https://www.uniprot.org/uniprotkb/Q15029/entry
- NCBI Gene 9343: https://www.ncbi.nlm.nih.gov/gene/9343
- Ensembl ENSG00000108883: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108883

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/)

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JSON: https://onco.cc/api/v1/entities/eftud2.json