# EGL-002

Source: https://onco.cc/drugs/egl-002/  
OnCo record `egl-002` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EGL-002 is an experimental anti-CCR8 / IL-2 mutein fusion antibody from Egle Therapeutics, in preclinical development for solid tumours.

## Summary

EGL-002 (anti-CCR8-IL2m) is an anti-CCR8 / IL-2 mutein fusion antibody (targeted IL-2m) from Egle Therapeutics. An anti-CCR8/IL-2 mutein fusion antibody engineered to enhance depletion of regulatory T cells in solid tumours; by binding both CCR8 and CD25 it stays on the surface of tumour-infiltrating Tregs longer. Its furthest stage is preclinical development, for solid tumours. No clinical trial naming it is registered on ClinicalTrials.gov. Homepage pipeline bar for anti-CCR8-IL2m fills Discovery and Preclinical, not IND-enabling; preclinical posters at AACR 2025. No registered trial found for EGL-002. It has not been shown to work in people.

## Fields

- Kind: Treatment
- Status: preclinical
- Last checked: 2026-11-03
- Also known as: anti-CCR8-IL2m
- Tags: pipeline
- Code: EGL-002
- Modality: Anti-CCR8 / IL-2 mutein fusion antibody (targeted IL-2m)
- Mechanism: An anti-CCR8/IL-2 mutein fusion antibody engineered to enhance depletion of regulatory T cells in solid tumours; by binding both CCR8 and CD25 it stays on the surface of tumour-infiltrating Tregs longer.

## Sources

- Egle Therapeutics: egle-tx.com: https://www.egle-tx.com/egle-therapeutics-to-highlight-novel-preclinical-findings-for-regulatory-t-cells-targeting-programs-egl-001-and-egl-002-with-poster-presentations-at-the-2025-aacr-annual-meeting/
- Egle Therapeutics: egle-tx.com: https://www.egle-tx.com/

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- targets: [CD25 (IL-2 receptor alpha)](https://onco.cc/targets/cd25/)
- companies: [Egle Therapeutics](https://onco.cc/companies/egle-therapeutics/)

---
JSON: https://onco.cc/api/v1/entities/egl-002.json