# EHBP1

Source: https://onco.cc/targets/ehbp1/  
OnCo record `ehbp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.18, genetic association 0.61, genetic literature 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: EH domain binding protein 1; EH domain-binding protein 1; KIAA0903; NACSIN
- Tags: cancer-genes-wave
- Symbol: EHBP1
- Class: other
- Biology: May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. Location: Cytoplasm; Membrane; Endosome (UniProt). Locus 2p15 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29144: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29144
- UniProt Q8NDI1: https://www.uniprot.org/uniprotkb/Q8NDI1/entry
- NCBI Gene 23301: https://www.ncbi.nlm.nih.gov/gene/23301
- Ensembl ENSG00000115504: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115504

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/ehbp1.json