# ELP1

Source: https://onco.cc/targets/elp1/  
OnCo record `elp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ELP1 (Elongator complex protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Medulloblastoma.

## Summary

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: elongator acetyltransferase complex subunit 1; Elongator complex protein 1; TOT1; IKI3; IKBKAP
- Tags: cancer-genes-wave
- Symbol: ELP1
- Class: other
- Biology: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Location: Cytoplasm; Nucleus (UniProt). Locus 9q31.3 (HGNC).
- Where found: Medulloblastoma: Open Targets association 0.72 with medulloblastoma (MONDO_0007959)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5959: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5959
- UniProt O95163: https://www.uniprot.org/uniprotkb/O95163/entry
- NCBI Gene 8518: https://www.ncbi.nlm.nih.gov/gene/8518
- Ensembl ENSG00000070061: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070061

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)

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JSON: https://onco.cc/api/v1/entities/elp1.json