# ELP4

Source: https://onco.cc/targets/elp4/  
OnCo record `elp4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.

## Summary

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.37, animal model 0.57, genetic association 0.80).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: elongator acetyltransferase complex subunit 4; Elongator complex protein 4; PAXNEB; C11orf19
- Tags: cancer-genes-wave
- Symbol: ELP4
- Class: other
- Biology: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Location: Cytoplasm; Nucleus (UniProt). Locus 11p13 (HGNC).
- Where found: Renal cell carcinoma: Open Targets association 0.50 with renal cell carcinoma (MONDO_0005086)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1171: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1171
- UniProt Q96EB1: https://www.uniprot.org/uniprotkb/Q96EB1/entry
- NCBI Gene 26610: https://www.ncbi.nlm.nih.gov/gene/26610
- Ensembl ENSG00000109911: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000109911

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/elp4.json