# EMSY

Source: https://onco.cc/targets/emsy/  
OnCo record `emsy` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EMSY (BRCA2-interacting transcriptional repressor EMSY) is a protein that switches other genes on and off. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.

## Summary

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Bevacizumab, Paclitaxel, Carboplatin and Talazoparib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: EMSY transcriptional repressor, BRCA2 interacting; BRCA2-interacting transcriptional repressor EMSY; C11orf30
- Tags: cancer-genes-wave
- Symbol: EMSY
- Class: transcription
- Biology: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. Location: Nucleus (UniProt). Locus 11q13.5 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Acral Lentiginous Melanoma.

## Sources

- HGNC HGNC:18071: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18071
- UniProt Q7Z589: https://www.uniprot.org/uniprotkb/Q7Z589/entry
- NCBI Gene 56946: https://www.ncbi.nlm.nih.gov/gene/56946
- Ensembl ENSG00000158636: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158636

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)

---
JSON: https://onco.cc/api/v1/entities/emsy.json