# Enoxaparin

Source: https://onco.cc/drugs/enoxaparin/  
OnCo record `enoxaparin` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Enoxaparin is a blood-thinning injection given under the skin. People with cancer have it to prevent clots after surgery or to treat a clot in a leg vein or the lungs.

## Summary

The Lovenox label covers prophylaxis of deep vein thrombosis in abdominal, hip and knee surgery and in acutely ill medical patients, inpatient and outpatient treatment of acute DVT, and acute coronary syndromes. ITAC 2022 recommends a low-molecular-weight heparin (LMWH) for the initial treatment of established venous thromboembolism in people with cancer when creatinine clearance is at least 30 mL/min (grade 1A), and prefers LMWHs over vitamin K antagonists for treatment (1A); where a twice-daily regimen is needed, it says only enoxaparin (1 mg/kg twice daily) can be used. The NDA was first approved on 29 March 1993.

## Fields

- Kind: Treatment
- Status: approved
- Last checked: 2026-11-11
- Also known as: enoxaparin sodium; Inhixa
- Tags: supportive; generic; supportive-care-gaps-2026-11
- Brand: Lovenox / Clexane
- Modality: Low-molecular-weight heparin (injection)
- Mechanism: A low-molecular-weight heparin: potentiates antithrombin, mainly against activated factor X.
- Approvals: US 1993: Prophylaxis of DVT in abdominal, hip and knee surgery and in medical patients with restricted mobility; treatment of acute DVT; acute coronary syndromes

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Enoxaparin_sodium
- US label (DailyMed): Lovenox: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3d263380-4f44-4fd8-aa2a-e69702ab258f
- Farge et al., 2022 international clinical practice guidelines (ITAC) for the treatment and prophylaxis of venous thromboembolism in patients with cancer (Lancet Oncol 2022): https://doi.org/10.1016/S1470-2045(22)00160-7

## Connected records

- drugs: [Apixaban](https://onco.cc/drugs/apixaban/), [Dalteparin](https://onco.cc/drugs/dalteparin/), [Edoxaban](https://onco.cc/drugs/edoxaban/), [Rivaroxaban](https://onco.cc/drugs/rivaroxaban/), [Tinzaparin](https://onco.cc/drugs/tinzaparin/), [Warfarin](https://onco.cc/drugs/warfarin/)
- technologies: [Cancer-associated thrombosis prevention and treatment](https://onco.cc/technologies/cancer-associated-thrombosis/)
- terms: [Venous thromboembolism (VTE)](https://onco.cc/terms/vte/)

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