# Eosinophilic solid and cystic renal cell carcinoma

Source: https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/  
OnCo record `eosinophilic-solid-cystic-renal-cell-carcinoma` (Cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Eosinophilic solid and cystic renal cell carcinoma is a recently named kidney cancer, almost always in women, made of pink cells in solid areas and cysts. It was first seen in people with tuberous sclerosis and then found on its own, it is nearly always confined to the kidney, and surgery cures it in almost every reported case.

## Summary

The 2022 WHO classification introduced eosinophilic solid and cystic renal cell carcinoma as a new morphologically defined type (Moch 2022). It was first described in patients with tuberous sclerosis complex; a search for a sporadic counterpart found 16 morphologically identical tumours, all in women without clinical tuberous sclerosis, median age 57, with solid and macrocystic growth, voluminous eosinophilic cytoplasm with granular stippling, hobnail cyst lining, nuclear PAX8, a CK20-positive and CK7-negative phenotype and no CD117; 13 of 16 were stage pT1 (Am J Surg Pathol 2016). In 19 further cases, all women, median age 55 and median size 31 mm, CK20 was positive in 74 percent, 89 percent were pT1, and 15 of 16 with follow-up were alive without disease (Am J Surg Pathol 2017). Sporadic cases carry somatic TSC1 or TSC2 mutations, the same pathway as the syndromic form.

How it differs from its parent: a female-only series, tuberous sclerosis biology (mTOR pathway), CK20 positivity and an indolent course with rare metastasis; it is distinguished from oncocytoma and chromophobe carcinoma by the cysts, the stippled cytoplasm and CK20.

How common: no registry share.

Treatment: partial nephrectomy; the mTOR inhibitor everolimus, approved for tuberous sclerosis-associated tumours, is the rational choice for the rare metastatic case, without trial evidence in this type.

## Fields

- Kind: Cancer
- Last checked: 2026-09-24
- Also known as: ESC RCC; Eosinophilic, solid and cystic renal cell carcinoma; TSC-associated eosinophilic renal cell carcinoma (syndromic form)
- Tags: subtype-page; wave4; kidney; rare
- Group: genitourinary
- Burden: Rare: 16 sporadic cases, all in women, median age 57 (Am J Surg Pathol 2016), and 19 further cases, all women, median age 55 (Am J Surg Pathol 2017). No registry share exists for a type named in 2022.
- Biomarkers: CK20 positive, CK7 negative, CD117 negative; Somatic or germline TSC1 or TSC2 mutation; Solid and cystic architecture with stippled eosinophilic cytoplasm; Stage (nearly always pT1)

## Sections of this record

The page is a hub with ten sections in reading order; large sections have their own page. The same plan as JSON: https://onco.cc/api/v1/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/sections.json

- Overview (on the hub): The TL;DR, the family this cancer belongs to, the organ, who gets it and what the state of the art is. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#overview
- What it is (on the hub): Anatomy, the subtypes and how they differ, how it is staged, and where advanced disease spreads. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#what-it-is
- Finding it (on the hub): How it shows itself, how it is confirmed, what screening exists, and the biomarkers clinicians test for. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#finding-it [4 biomarkers]
- Treating it (on the hub): The standard of care by setting, the medicines, surgery and radiotherapy named in it, and the regimens behind them. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#treating-it [1 setting]
- Evidence (on the hub): Trials recruiting now, the landmark trials, the key papers and what they mean, the latest literature, and the milestones year by year. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#evidence
- The science (on the hub): The molecular landscape: the targets and how often each appears, the pathways, the mechanics stages and the preclinical models. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#science [2 targets]
- Where you are (own page): Cases by country, the UK and NHS pathway and other country lenses, and the expert centres with trials on record. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/where-you-are/
- Living with it (on the hub): The decisions you may face, the aids that walk through them, the warnings on record, the first sixty days and the questions to ask. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/#living-with-it [7 questions, 3 red cards]
- What is coming (own page): Everything in development, the open problems and what is being done about them, the roadmaps, and what changed on this record. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/coming/ [1 medicine]
- Data (own page): Every connected record, the notes, the JSON, Markdown and RDF twins, and where the record came from and when it was checked. https://onco.cc/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/data/ [7 connected records]

## Standard of care

- All stages: Partial nephrectomy; everolimus is the rational choice for rare metastatic disease on the tuberous sclerosis biology, without trial evidence. ([Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Nephrectomy](https://onco.cc/terms/nephrectomy/), [Everolimus](https://onco.cc/drugs/everolimus/))

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Renal_cell_carcinoma
- Moch 2022, European Urology: the 2022 WHO classification of urinary and male genital tumours, part A (renal, penile, testicular): https://doi.org/10.1016/j.eururo.2022.06.016
- Am J Surg Pathol 2016: eosinophilic, solid and cystic renal cell carcinoma, 16 sporadic cases in women: https://doi.org/10.1097/pas.0000000000000508
- Am J Surg Pathol 2017: eosinophilic solid and cystic RCC, further characterisation of 19 cases: https://doi.org/10.1097/pas.0000000000000838

## Connected records

- cancers: [Chromophobe renal cell carcinoma](https://onco.cc/cancers/chromophobe-rcc/), [Mucinous tubular and spindle cell carcinoma of the kidney](https://onco.cc/cancers/mucinous-tubular-spindle-cell-carcinoma/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Succinate dehydrogenase-deficient renal cell carcinoma](https://onco.cc/cancers/sdh-deficient-renal-cell-carcinoma/)
- drugs: [Everolimus](https://onco.cc/drugs/everolimus/)
- terms: [Nephrectomy](https://onco.cc/terms/nephrectomy/)

---
JSON: https://onco.cc/api/v1/entities/eosinophilic-solid-cystic-renal-cell-carcinoma.json