# EPHA10

Source: https://onco.cc/targets/epha10/  
OnCo record `epha10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.

## Summary

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.03, clinical 0.93).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: EPH receptor A10; Ephrin type-A receptor 10; FLJ16103; FLJ33655
- Tags: cancer-genes-wave
- Symbol: EPHA10
- Class: other
- Biology: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Location: Cell membrane; Secreted (UniProt). Locus 1p34.3 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.56 with thyroid cancer (MONDO_0002108); Neuroendocrine tumours: Open Targets association 0.54 with neuroendocrine neoplasm (MONDO_0019496)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19987: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19987
- UniProt Q5JZY3: https://www.uniprot.org/uniprotkb/Q5JZY3/entry
- NCBI Gene 284656: https://www.ncbi.nlm.nih.gov/gene/284656
- Ensembl ENSG00000183317: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183317

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Thyroid cancer](https://onco.cc/cancers/thyroid/)

---
JSON: https://onco.cc/api/v1/entities/epha10.json