# EPHB1

Source: https://onco.cc/targets/ephb1/  
OnCo record `ephb1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EPHB1 (Ephrin type-B receptor 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.

## Summary

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells. The signalling pathway downstream of the receptor is referred to as forward signalling while the signalling pathway downstream of the ephrin ligand is referred to as reverse signalling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.93, animal model 0.47, genetic association 0.35, clinical 0.93).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: EPH receptor B1; Ephrin type-B receptor 1; Hek6; EPHT2
- Tags: cancer-genes-wave
- Symbol: EPHB1
- Class: kinase
- Biology: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells. The signalling pathway downstream of the receptor is referred to as forward signalling while the signalling pathway downstream of the ephrin ligand is referred to as reverse signalling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Location: Cell membrane; Early endosome membrane; Cell projection, dendrite (UniProt). Locus 3q22.2 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.56 with thyroid cancer (MONDO_0002108); Neuroendocrine tumours: Open Targets association 0.54 with neuroendocrine neoplasm (MONDO_0019496)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3392: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3392
- UniProt P54762: https://www.uniprot.org/uniprotkb/P54762/entry
- NCBI Gene 2047: https://www.ncbi.nlm.nih.gov/gene/2047
- Ensembl ENSG00000154928: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154928

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/ephb1.json