# EPS15

Source: https://onco.cc/targets/eps15/  
OnCo record `eps15` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EPS15 (Epidermal growth factor receptor substrate 15) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Non-Hodgkin lymphoma and 2 more.

## Summary

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.35, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: epidermal growth factor receptor pathway substrate 15; Epidermal growth factor receptor substrate 15; AF-1P; MLLT5
- Tags: cancer-genes-wave
- Symbol: EPS15
- Class: oncogene
- Biology: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Location: Cytoplasm; Cell membrane; Membrane, clathrin-coated pit; Early endosome membrane (UniProt). Locus 1p32.3 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 1 cohort (PRAD); Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254); Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898); Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3419: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3419
- UniProt P42566: https://www.uniprot.org/uniprotkb/P42566/entry
- NCBI Gene 2060: https://www.ncbi.nlm.nih.gov/gene/2060
- Ensembl ENSG00000085832: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085832

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/eps15.json