# ERBIN

Source: https://onco.cc/targets/erbin/  
OnCo record `erbin` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.04, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: erbb2 interacting protein; Erbin; LAP2; ERBB2IP
- Tags: cancer-genes-wave
- Symbol: ERBIN
- Class: other
- Biology: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion. Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes. Location: Cell junction, hemidesmosome; Nucleus membrane; Basolateral cell membrane; Cytoplasm (UniProt). Locus 5q12.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:15842: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15842
- UniProt Q96RT1: https://www.uniprot.org/uniprotkb/Q96RT1/entry
- NCBI Gene 55914: https://www.ncbi.nlm.nih.gov/gene/55914
- Ensembl ENSG00000112851: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112851

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/erbin.json