# ERC1

Source: https://onco.cc/targets/erc1/  
OnCo record `erc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.38, animal model 0.42, genetic association 0.08, somatic mutation 0.92).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ELKS/RAB6-interacting/CAST family member 1; ELKS/Rab6-interacting/CAST family member 1; KIAA1081; CAST2; MGC12974; RAB6IP2
- Tags: cancer-genes-wave
- Symbol: ERC1
- Class: other
- Biology: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm; Membrane; Golgi apparatus membrane (UniProt). Locus 12p13.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17072: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17072
- UniProt Q8IUD2: https://www.uniprot.org/uniprotkb/Q8IUD2/entry
- NCBI Gene 23085: https://www.ncbi.nlm.nih.gov/gene/23085
- Ensembl ENSG00000082805: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000082805

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/erc1.json