# ERCC2

Source: https://onco.cc/targets/ercc2/  
OnCo record `ercc2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ERCC2 (General transcription and DNA repair factor IIH helicase subunit XPD) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Skin cancer, Colorectal cancer and 5 more.

## Summary

ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognises damaged bases.

CIViC holds 23 clinical evidence items and 0 assertions across 15 variants, naming Chemotherapy, Immune Checkpoint Inhibitor, Paclitaxel and Carboplatin and others. Open Targets scores its association with cancer at 0.83 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.61, literature 0.99, genetic association 0.62, somatic mutation 0.95, animal model 0.60). IntOGen calls it a driver in 6 cohorts (6 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ERCC excision repair 2, TFIIH core complex helicase subunit; General transcription and DNA repair factor IIH helicase subunit XPD; EM9; MGC102762; MGC126218; MGC126219
- Tags: cancer-genes-wave
- Symbol: ERCC2
- Class: oncogene
- Biology: ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognises damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. Location: Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 19q13.32 (HGNC).
- Where found: Bladder & urothelial cancer: Open Targets association 0.73 with urinary bladder cancer (MONDO_0001187); CIViC evidence names this disease; Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575); Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056); Melanoma: Open Targets association 0.58 with melanoma (MONDO_0005105); CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; IntOGen calls it an activating (Act) driver in 6 cohorts; CIViC holds 23 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3434: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3434
- UniProt P18074: https://www.uniprot.org/uniprotkb/P18074/entry
- NCBI Gene 2068: https://www.ncbi.nlm.nih.gov/gene/2068
- Ensembl ENSG00000104884: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104884

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Osteosarcoma](https://onco.cc/cancers/osteosarcoma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

---
JSON: https://onco.cc/api/v1/entities/ercc2.json