# ERCC4

Source: https://onco.cc/targets/ercc4/  
OnCo record `ercc4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ERCC4 (DNA repair endonuclease XPF) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Skin cancer, Myeloproliferative neoplasms and 4 more.

## Summary

Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.

CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Immune Checkpoint Inhibitor. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.61, literature 0.98, genetic association 0.63, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ERCC excision repair 4, endonuclease catalytic subunit; DNA repair endonuclease XPF; RAD1; FANCQ
- Tags: cancer-genes-wave
- Symbol: ERCC4
- Class: enzyme
- Biology: Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. Location: Nucleus; Chromosome (UniProt). Locus 16p13.12 (HGNC).
- Where found: Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076); Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575); Melanoma: Open Targets association 0.54 with melanoma (MONDO_0005105); CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3436: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3436
- UniProt Q92889: https://www.uniprot.org/uniprotkb/Q92889/entry
- NCBI Gene 2072: https://www.ncbi.nlm.nih.gov/gene/2072
- Ensembl ENSG00000175595: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175595

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Melanoma](https://onco.cc/cancers/melanoma/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/ercc4.json