# ERCC6

Source: https://onco.cc/targets/ercc6/  
OnCo record `ercc6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ERCC6 (Chimeric ERCC6-PGBD3 protein) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.

## Summary

Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Fluorouracil. Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.61, animal model 0.47, genetic association 0.91).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ERCC excision repair 6, chromatin remodeling factor; Chimeric ERCC6-PGBD3 protein; RAD26; ARMD5; CKN2
- Tags: cancer-genes-wave
- Symbol: ERCC6
- Class: other
- Biology: Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterised by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. Location: Nucleus (UniProt). Locus 10q11.23 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease; Lung cancer: Open Targets association 0.57 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3438: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3438
- UniProt P0DP91: https://www.uniprot.org/uniprotkb/P0DP91/entry
- NCBI Gene 2074: https://www.ncbi.nlm.nih.gov/gene/2074
- Ensembl ENSG00000225830: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000225830

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/ercc6.json