# EREG

Source: https://onco.cc/targets/ereg/  
OnCo record `ereg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EREG (Proepiregulin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Non-small-cell lung cancer.

## Summary

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.

CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Cetuximab and Panitumumab. Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.88, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: epiregulin; Proepiregulin
- Tags: cancer-genes-wave
- Symbol: EREG
- Class: other
- Biology: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 4q13.3 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease; Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3443: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3443
- UniProt O14944: https://www.uniprot.org/uniprotkb/O14944/entry
- NCBI Gene 2069: https://www.ncbi.nlm.nih.gov/gene/2069
- Ensembl ENSG00000124882: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124882

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/ereg.json