# ERLIN2

Source: https://onco.cc/targets/erlin2/  
OnCo record `erlin2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.95, genetic association 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ER lipid raft associated 2; Erlin-2; NET32; C8orf2; SPFH2; SPG18
- Tags: cancer-genes-wave
- Symbol: ERLIN2
- Class: other
- Biology: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway. May promote ER retention of the SCAP-SREBF complex. Location: Endoplasmic reticulum membrane (UniProt). Locus 8p11.23 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1356: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1356
- UniProt O94905: https://www.uniprot.org/uniprotkb/O94905/entry
- NCBI Gene 11160: https://www.ncbi.nlm.nih.gov/gene/11160
- Ensembl ENSG00000147475: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147475

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/erlin2.json