# ESRP1

Source: https://onco.cc/targets/esrp1/  
OnCo record `esrp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT).

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.89, animal model 0.64, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: epithelial splicing regulatory protein 1; Epithelial splicing regulatory protein 1; FLJ20171; RBM35A
- Tags: cancer-genes-wave
- Symbol: ESRP1
- Class: other
- Biology: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. Location: Nucleus (UniProt). Locus 8q22.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25966: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25966
- UniProt Q6NXG1: https://www.uniprot.org/uniprotkb/Q6NXG1/entry
- NCBI Gene 54845: https://www.ncbi.nlm.nih.gov/gene/54845
- Ensembl ENSG00000104413: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104413

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/esrp1.json