# ESRRA

Source: https://onco.cc/targets/esrra/  
OnCo record `esrra` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ESRRA (Steroid hormone receptor ERR1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers and Adenoid cystic carcinoma.

## Summary

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adenoid Cystic Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: estrogen related receptor alpha; Steroid hormone receptor ERR1; ERR1; ERRalpha; NR3B1; ERRa; ESRL1
- Tags: cancer-genes-wave
- Symbol: ESRRA
- Class: oncogene
- Biology: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerisation and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. Location: Nucleus; Cytoplasm (UniProt). Locus 11q13.1 (HGNC).
- Where found: Salivary gland cancers: IntOGen driver in 1 cohort (ACYC); Adenoid cystic carcinoma: IntOGen driver in 1 cohort (ACYC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3471: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3471
- UniProt P11474: https://www.uniprot.org/uniprotkb/P11474/entry
- NCBI Gene 2101: https://www.ncbi.nlm.nih.gov/gene/2101
- Ensembl ENSG00000173153: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000173153

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Adenoid cystic carcinoma](https://onco.cc/cancers/adenoid-cystic-carcinoma/), [Salivary gland cancers](https://onco.cc/cancers/salivary-gland/)

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JSON: https://onco.cc/api/v1/entities/esrra.json