# ETNK1

Source: https://onco.cc/targets/etnk1/  
OnCo record `etnk1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.

## Summary

Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.18, somatic mutation 0.97).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ethanolamine kinase 1; Ethanolamine kinase 1; EKI1
- Tags: cancer-genes-wave
- Symbol: ETNK1
- Class: kinase
- Biology: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Location: Cytoplasm (UniProt). Locus 12p12.1 (HGNC).
- Where found: Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059); Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254); Myeloproliferative neoplasms: Open Targets association 0.51 with myeloproliferative neoplasm (MONDO_0020076)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24649: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24649
- UniProt Q9HBU6: https://www.uniprot.org/uniprotkb/Q9HBU6/entry
- NCBI Gene 55500: https://www.ncbi.nlm.nih.gov/gene/55500
- Ensembl ENSG00000139163: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139163

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/etnk1.json