# ETS1

Source: https://onco.cc/targets/ets1/  
OnCo record `ets1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ETS1 (ETS proto-oncogene 1, transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ETS proto-oncogene 1, transcription factor; FLJ10768; ETS-1; EWSR2
- Tags: cancer-genes-wave
- Symbol: ETS1
- Class: transcription
- Biology: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Acts as a dominant-negative for isoform c-ETS-1A. Location: Nucleus; Cytoplasm (UniProt). Locus 11q24.3 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3488: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3488
- UniProt P14921: https://www.uniprot.org/uniprotkb/P14921/entry
- NCBI Gene 2113: https://www.ncbi.nlm.nih.gov/gene/2113
- Ensembl ENSG00000134954: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134954

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/ets1.json