# ETS2

Source: https://onco.cc/targets/ets2/  
OnCo record `ets2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ETS2 (ETS proto-oncogene 2, transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.

## Summary

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel and Cisplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ETS proto-oncogene 2, transcription factor
- Tags: cancer-genes-wave
- Symbol: ETS2
- Class: transcription
- Biology: Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. Location: Nucleus (UniProt). Locus 21q22.2 (HGNC).
- Where found: Non-small-cell lung cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3489: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3489
- UniProt P15036: https://www.uniprot.org/uniprotkb/P15036/entry
- NCBI Gene 2114: https://www.ncbi.nlm.nih.gov/gene/2114
- Ensembl ENSG00000157557: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157557

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/ets2.json