# ExpreS2ion Biotechnologies

Source: https://onco.cc/companies/expres2ion-biotechnologies/  
OnCo record `expres2ion-biotechnologies` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ExpreS2ion Biotechnologies makes ES2B-C001, a vaccine that trains the immune system to recognise HER2, a protein found on some breast and other cancers. It is in a first trial in people with HER2-expressing breast cancer that has spread.

## Summary

ExpreS2ion Biotechnologies is a clinical-stage company listed on the Nasdaq First North Growth Market in Sweden, with research and development in Hørsholm, Denmark, and a holding company address in Helsingborg, Sweden. It develops immunotherapies using its proprietary ExpreS2 protein expression system. Its lead programme ES2B-C001 is an active immunotherapy for HER2-expressing cancers that combines HER2 antigens with a virus-like particle delivery system and is designed to target all four extracellular domains of the HER2 receptor; a first-in-human phase 1 trial assesses safety with or without an adjuvant in patients with HER2-expressing metastatic breast cancer. Its first registered cancer trial, NCT06746688, was posted on ClinicalTrials.gov in December 2024.

## Fields

- Kind: Company
- Last checked: 2026-10-29
- Also known as: ExpreS2ion
- HQ: Hørsholm
- Type: biotech
- Website: https://expres2ionbio.com/

## Notes

- Founding year not stated on the company website.
- The company website blocked automated requests; its content was read through a fetch tool that summarises pages, so wording was checked only against that summary and the registry record.
- The ticker symbol was not shown on the page read and is not recorded.
- No financing rounds were read; none are recorded.
- Read on 29 October 2026.

## Sources

- Official website: https://expres2ionbio.com/
- ClinicalTrials.gov: first-in-human trial of ES2B-C001 in HER2-expressing metastatic breast cancer (NCT06746688): https://clinicaltrials.gov/study/NCT06746688

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- fronts: [Immunotherapy](https://onco.cc/fronts/immunotherapy/)
- technologies: [Off-the-shelf cancer vaccines](https://onco.cc/technologies/shared-antigen-vaccine/)
- targets: [HER2](https://onco.cc/targets/her2/)

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JSON: https://onco.cc/api/v1/entities/expres2ion-biotechnologies.json