# EZR

Source: https://onco.cc/targets/ezr/  
OnCo record `ezr` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.

## Summary

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.99, animal model 0.50, genetic association 0.00, somatic mutation 0.91).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ezrin; Ezrin; VIL2
- Tags: cancer-genes-wave
- Symbol: EZR
- Class: other
- Biology: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Location: Apical cell membrane; Cell projection; Cell projection, microvillus membrane; Cell projection, ruffle membrane (UniProt). Locus 6q25.3 (HGNC).
- Where found: Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:12691: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12691
- UniProt P15311: https://www.uniprot.org/uniprotkb/P15311/entry
- NCBI Gene 7430: https://www.ncbi.nlm.nih.gov/gene/7430
- Ensembl ENSG00000092820: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000092820

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/ezr.json