# FAAP20

Source: https://onco.cc/targets/faap20/  
OnCo record `faap20` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognises and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Interventional Radiology Procedure and PARP Inhibitor AZD2461.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA core complex associated protein 20; Fanconi anemia core complex-associated protein 20; FLJ31031; C1orf86
- Tags: cancer-genes-wave
- Symbol: FAAP20
- Class: other
- Biology: Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognises and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. Location: Nucleus; Chromosome (UniProt). Locus 1p36.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:26428: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26428
- UniProt Q6NZ36: https://www.uniprot.org/uniprotkb/Q6NZ36/entry
- NCBI Gene 199990: https://www.ncbi.nlm.nih.gov/gene/199990
- Ensembl ENSG00000162585: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162585

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/faap20.json