# FAM114A2

Source: https://onco.cc/targets/fam114a2/  
OnCo record `fam114a2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FAM114A2 (family with sequence similarity 114 member A2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

UniProt has no function text for Q9NRY5; HGNC names it "family with sequence similarity 114 member A2".

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.12, affected pathway 0.89, genetic association 0.03).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: family with sequence similarity 114 member A2; 133K02; C5orf3
- Tags: cancer-genes-wave
- Symbol: FAM114A2
- Class: other
- Biology: UniProt has no function text for Q9NRY5; HGNC names it "family with sequence similarity 114 member A2". Locus 5q33.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1333: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1333
- UniProt Q9NRY5: https://www.uniprot.org/uniprotkb/Q9NRY5/entry
- NCBI Gene 10827: https://www.ncbi.nlm.nih.gov/gene/10827
- Ensembl ENSG00000055147: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000055147

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fam114a2.json