# FAM135B

Source: https://onco.cc/targets/fam135b/  
OnCo record `fam135b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.

## Summary

UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B".

IntOGen calls it a driver in 9 cohorts (3 activating, 6 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour, Well-Differentiated Thyroid Cancer.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: family with sequence similarity 135 member B; C8ORFK32
- Tags: cancer-genes-wave
- Symbol: FAM135B
- Class: tumor-suppressor
- Biology: UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B". Locus 8q24.23 (HGNC).
- Where found: Head and neck squamous cell carcinoma: IntOGen driver in 2 cohorts (HNSC); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Endometrial cancer: IntOGen driver in 1 cohort (UCEC); Thyroid cancer: IntOGen driver in 1 cohort (WDTC); Non-small-cell lung cancer: IntOGen driver in 3 cohorts (LUSC); Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 6 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:28029: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28029
- UniProt Q49AJ0: https://www.uniprot.org/uniprotkb/Q49AJ0/entry
- NCBI Gene 51059: https://www.ncbi.nlm.nih.gov/gene/51059
- Ensembl ENSG00000147724: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147724

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Papillary thyroid cancer](https://onco.cc/cancers/papillary-thyroid-cancer/), [Thyroid cancer](https://onco.cc/cancers/thyroid/), [Uterine carcinosarcoma](https://onco.cc/cancers/uterine-carcinosarcoma/)

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JSON: https://onco.cc/api/v1/entities/fam135b.json